Users generally do not communicate directly with a DNS resolver. Instead DNS resolution is handled transparently via client applications such as web browsers (Internet Explorer, Mozilla Firefox, Safari, Opera, etc), mail clients (Outlook Express, Mozilla Thunderbird, etc), and other Internet applications. When a request is made which necessitates a DNS lookup, such programs send a resolution request to the local DNS resolver in the operating system which in turn handles the communications required.

The DNS resolver will almost invariably have a cache (see above) containing recent lookups. If the cache can provide the answer to the request, the resolver will return the value in the cache to the program that made the request. If the cache does not contain the answer, the resolver will send the request to a designated DNS server or servers. In the case of most home users, the Internet service provider to which the machine connects will usually supply this DNS server: such a user will either configure that server's address manually or allow DHCP to set it; however, where systems administrators have configured systems to use their own DNS servers, their DNS resolvers will generally point to their own nameservers.

This name server will then follow the process outlined above in DNS in theory, until it either successfully finds a result, or does not. It then returns its results to the DNS resolver; assuming it has found a result, the resolver duly caches that result for future use, and hands the result back to the software which initiated the request.